منابع مشابه
Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability.
Thiazide diuretics are one of the preferred pharmacologic treatments for hypertension. Hydrochlorothiazide and chlorthalidone have been the 2 most commonly used diuretics in major clinical trials. Treatment guidelines and compendia often consider these 2 drugs interchangeable agents within the class of thiazide or thiazide-like diuretics. Many sources list them as equipotent. Despite these beli...
متن کاملChlorthalidone versus hydrochlorothiazide: a tale of tortoises and a hare.
Chlorthalidone (CTD) is the best diuretic for the treatment of hypertension, both in blood pressure–lowering efficacy and, most importantly, in prevention of hypertensionrelated morbidity and mortality. Despite this fact, hydrochlorothiazide (HCTZ) has been and continues to be by far the most frequently prescribed diuretic in the United States.1 Even among patients with resistant hypertension, ...
متن کاملChlorthalidone vs. Hydrochlorothiazide for Treatment of Hypertension.
Evidence-Based Answer Chlorthalidone produces slightly greater reductions in blood pressure compared with hydrochlorothiazide (HCTZ), but it is associated with greater declines in serum potassium levels. (Strength of Recommendation [SOR]: C, based on a meta-analysis of disease-oriented evidence.) Chlorthalidone lowers the risk of cardiovascular events about 18% more than HCTZ at the same achiev...
متن کاملChlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study.
BACKGROUND Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension. OBJECTIVE To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in older adults. DESIGN Propensity score-matched observational cohort study with up to 5 years of follow-up. SETTING Ontario, Canada. PATIENTS All individuals aged 66 ye...
متن کاملChlorthalidone versus hydrochlorothiazide as the preferred diuretic: is there a verdict yet?
In this issue of Hypertension, the retrospective observational cohort analysis of the Multiple Risk Factor Intervention Trial by Dorsch et al1 adds to the growing body of evidence supporting the superiority of chlorthalidone over hydrochlorothiazide (HCTZ) as the preferred diuretic in the treatment of hypertension. In the absence of a randomized, controlled clinical end point trial directly com...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2011
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.111.183525